Get Neurofibromatosis Type 1: Molecular and Cellular Biology PDF

By Meena Upadhyaya,David N Cooper

Neurofibromatosis kind 1 (NF1), attributable to mutational inactivation of the NF1 tumour suppressor gene, is likely one of the commonest dominantly inherited human problems, affecting 1 in 3000 participants world wide. This ebook offers in concise type, yet as comprehensively as attainable, our present nation of information at the molecular genetics, molecular biology and mobile biology of this tumour predisposition syndrome.

Written by way of the world over famous specialists within the box, the forty four chapters that represent this edited quantity give you the reader with a huge evaluation of the scientific positive aspects of the sickness, the constitution and expression of the NF1 gene, its germ line and somatic mutational spectra and genotype-phenotype relationships, the constitution and serve as of its protein product (neurofibromin), NF1 enhancing loci, the molecular pathology of NF1-associated tumours, animal types of the sickness, psycho-social features and destiny customers for healing treatment.

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Neurofibromatosis Type 1: Molecular and Cellular Biology by Meena Upadhyaya,David N Cooper

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