Clemens Sonntag's Free-Radical-Induced DNA Damage and Its Repair: A Chemical PDF

By Clemens Sonntag

The free-radical chemistry of DNA have been mentioned in a few element in 1987 in my publication The Chemical foundation of Radiation Biology. evidently, the newer advancements and the concomitant larger point of figuring out of mechanistic info are lacking. furthermore, within the residing mobile, free-radical DNA harm is not just precipitated via ionizing radiation, yet free-radical-induced DNA harm is a way more normal phenomenon. It used to be, for that reason, felt that it truly is now well timed to study our current wisdom of free-radical-induced DNA harm precipitated by means of all feasible free-radical-generating assets. initially, it have been idea to incorporate additionally a vital point, the fix of DNA harm by way of the cell’s a number of fix enzymes. Kevin Prise (Cancer crusade, grey Laboratory, L- don) was once so style to comply with write this half. although, an enough description of this strongly increasing quarter could have surpassed the allotted house by way of a lot, and this part needed to be passed over. the administrators of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to proceed to take advantage of its amenities after my retirement in 2001. particularly, our - brarian, Mrs. Jutta Theurich, and her right-hand aid, Mrs. Rosemarie Schr- er, have been such a lot beneficial in getting carry of the literature. I thank them greatly. with no their consistent support, this might were very tricky indeed.

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Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective by Clemens Sonntag


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