By Alex Avdeef
Explains the right way to practice and examine the result of the most recent physicochemical methods
With this ebook as their advisor, readers have entry to the entire present info had to completely examine and properly ensure a compound's pharmaceutical homes and their results on drug absorption. The ebook emphasizes oral absorption, explaining all of the physicochemical tools used at the present time to investigate drug applicants. additionally, the writer offers specialist advice to assist readers examine the result of their stories so that it will decide upon the main promising drug candidates.
This Second Edition has been completely up-to-date and revised, incorporating all of the newest examine findings, equipment, and assets, including:
Descriptions and functions of latest PAMPA versions, drawing on greater than thirty papers released by means of the author's study group
Two new chapters reading permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded info and techniques to aid pKa determination
New examples explaining the therapy of virtually insoluble try compounds
Additional case reports demonstrating using the newest physicochemical techniques
New, revised, and improved database tables during the book
Well over two hundred drawings aid readers larger comprehend tricky options and supply a visible consultant to advanced tactics. furthermore, over 800 references function a gateway to the first literature within the box, facilitating extra learn into the entire themes lined within the book.
This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar components of analysis. it's also steered as a supplemental textual content for graduate classes in pharmaceutics.
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Extra info for Absorption and Drug Development: Solubility, Permeability, and Charge State
Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef